Gene therapy utilizing drug resistance genes: A review

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1994 English Publisher:Oxford University Press (OUP)Journal:STEM CELLS, volume 12, pages 378-385 (issn: 1066-5099, eissn: 1549-4918,

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Authors: D, Banerjee; S C, Zhao; M X, Li; B I, Schweitzer; S, Mineishi; J R, Bertino;

doi: 10.1002/stem.5530120404

pmid: 7951004

Gene therapy utilizing drug resistance genes: A review

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Abstract

The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.

Related Organizations

Memorial Sloan Kettering Cancer Center
United States

Keywords

Genetic Vectors, Drug Resistance, Hematopoietic Stem Cell Transplantation, Antineoplastic Agents, Bone Marrow Cells, CHO Cells, Genetic Therapy, Haplorhini, Hematopoietic Stem Cells, Mice, Tetrahydrofolate Dehydrogenase, Dogs, Cricetinae, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1

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