AbstractThis paper begins with the story that systems science, born of modern Western civilization, began to pay attention to traditional Eastern wisdom to deal with management issues. The consequence of the story is that we should complementarily utilize quantitative and rational analysis results and qualitative and intuitive empirical knowledge to solve problems. As a methodology for implementing knowledge synthesis, this paper presents the knowledge construction systems methodology that promotes knowledge management enhanced by systems thinking. Based on this methodology, it introduces the concept of knowledge synthesis enablers, which are conditions or activities that facilitate knowledge synthesis when promoting research and businesses. This paper shows some results of covariance structure analysis using the evaluation data of applied systems research projects and examines the validity of the assumed enabler candidates.