AbstractWe study the application of a data‐enabled predictive control (DeePC) algorithm for position control of real‐world nano‐quadcopters. The DeePC algorithm is a finite‐horizon, optimal control method that uses input/output measurements from the system to predict future trajectories without the need for system identification or state estimation. The algorithm predicts future trajectories of the quadcopter by linearly combining previously measured trajectories (motion primitives). We illustrate the necessity of a regularized variant of the DeePC algorithm to handle the nonlinear nature of the real‐world quadcopter dynamics with noisy measurements. Simulation‐based analysis is used to gain insights into the effects of regularization, and experimental results validate that these insights carry over to the real‐world quadcopter. Moreover, we demonstrate the reliability of the DeePC algorithm by collecting a new set of input/output measurements for every real‐world experiment performed. The performance of the DeePC algorithm is compared to Model Predictive Control based on a first‐principles model of the quadcopter. The results are demonstrated with a video of successful trajectory tracking of the real‐world quadcopter.