SummaryIn this paper, an adaptive fault‐tolerant time‐varying formation control problem for nonlinear multiagent systems with multiple leaders is studied against actuator faults and state‐dependent uncertainties. Simultaneously, the followers form a predefined formation while tracking reference signal determined by the convex combination of the multiple leaders. Based on the neighboring relative information, an adaptive fault‐tolerant formation time‐varying control protocol is constructed to compensate for the influences of actuator faults and model uncertainties. In addition, the updating laws can be adjusted online through the adaptive mechanism, and the proposed control protocol can guarantee that all the signals in the closed‐loop systems are bounded. Lyapunov‐like functions are addressed to prove the stability of multiagent systems. Finally, two examples are provided to demonstrate the effectiveness of the theoretical results.