The enzymic conversion of all‐cis 8,11,14‐eicosatrienoic acid into prostaglandin E1

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1966 English Publisher:WileyJournal:Recueil des Travaux Chimiques des Pays-Bas, volume 85, pages 405-419 (issn: 0165-0513, eissn: 0165-0513,

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Authors: D. H. Nugteren; H. Vonkeman; D. A. van Dorp;

doi: 10.1002/recl.19660850412 , 10.1002/recl.19670861109

The enzymic conversion of all‐cis 8,11,14‐eicosatrienoic acid into prostaglandin E1

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Abstract

AbstractIn the biosynthesis of prostaglandin E1 (PGE1) with an enzyme fraction of sheep vesicular glands glutathione and a moderate amount of antioxidant are required to obtain maximum yield; two oxygen molecules are consumed per mole PGE1 formed. By altering the incubation conditions, besides PGE1 various other products can be obtained.A scheme for the mechanism of the conversion is proposed in which the formation of PGE1 as well as that of the byproducts is assumed to occur on the enzyme in concerted reactions via peroxy‐radicals and a cyclic peroxide.

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