Drug interaction potential of the seed extract ofUrtica urensL. (dwarf Nettle)
Copyright policy )Drug interaction potential of the seed extract ofUrtica urensL. (dwarf Nettle)
AbstractDwarf nettle (Urtica urens) seed extract was examinedin vivoin the rat for its potential to modulate drug metabolizing enzymes including aminopyrineN‐demethylase (APND; CYP2C6), aniline 4‐hydroxylase (A4H; CYP2E1), nitrosodimethylamineN‐demethylase (NDMA‐ND; CYP2E1) erythromycinN‐demethylase (ERND; CYP3A1) CYP2D1/2 and glutathioneS‐transferase (GST). RT‐PCR data and western blotting studies clearly demonstrated that CYP2C6 and CYP2E1 mRNA levels were substantially increased after Urtica treatment, while the level of CYP3A1 mRNA decreased and that of CYP2D1/2 remained unchanged. Urtica treatment significantly induced GST activity in the liver, lung and kidney (66‐, 46‐ and 31‐fold, respectively) while decreasing that of APND (35‐, 61‐ and 94‐fold) and NDMA‐ND (23, 28 and 54‐fold). ERND activity in liver was reduced 45‐fold, but increased in the lung and kidney (78‐ and 144‐fold) after Urtica treatment. These results indicate that Urtica seed extract may have the potential to inhibit and/or induce the metabolism of certain co‐administered drugs. Copyright © 2009 John Wiley & Sons, Ltd.
- Pamukkale University Turkey
Male, CYP2C6, CYP3A1, tissue distribution, Wistar, Kidney, Animals; Cytochrome P-450 Enzyme System/metabolism; Enzyme Inhibitors/*pharmacology; Glutathione Transferase/metabolism; *Herb-Drug Interactions; Kidney/enzymology; Liver/enzymology; Lung/enzymology; Male; Plant Extracts/*pharmacology; Rats; Rats, Wistar; Seeds/chemistry; Urticaceae/*chemistry, Western blotting, medicinal plant, Cytochrome P-450 Enzyme System, glutathione transferase, rat, Enzyme Inhibitors, Urticaceae, Lung, Glutathione Transferase, messenger RNA, Urtica urens extract, article, RNA analysis, unclassified drug, enzyme activity, Liver, Seeds, plant extract, cytochrome P450 3A1, kidney, urtica urens, enzyme localization, animal experiment, Herb-Drug Interactions, 610, liver, lung, in vivo study, reverse transcription polymerase chain reaction, male, Animals, controlled study, CYP2E1, cytochrome P450 2D1, Rats, Wistar, enzyme analysis, dimethylnitrosamine demethylase, nonhuman, Rattus, Plant Extracts, plant seed, Rats, Urtica urens, aminopyrine n demethylase, cytochrome P450 2E1, Urtica, dwarf nettle, CYP2D1/2
Male, CYP2C6, CYP3A1, tissue distribution, Wistar, Kidney, Animals; Cytochrome P-450 Enzyme System/metabolism; Enzyme Inhibitors/*pharmacology; Glutathione Transferase/metabolism; *Herb-Drug Interactions; Kidney/enzymology; Liver/enzymology; Lung/enzymology; Male; Plant Extracts/*pharmacology; Rats; Rats, Wistar; Seeds/chemistry; Urticaceae/*chemistry, Western blotting, medicinal plant, Cytochrome P-450 Enzyme System, glutathione transferase, rat, Enzyme Inhibitors, Urticaceae, Lung, Glutathione Transferase, messenger RNA, Urtica urens extract, article, RNA analysis, unclassified drug, enzyme activity, Liver, Seeds, plant extract, cytochrome P450 3A1, kidney, urtica urens, enzyme localization, animal experiment, Herb-Drug Interactions, 610, liver, lung, in vivo study, reverse transcription polymerase chain reaction, male, Animals, controlled study, CYP2E1, cytochrome P450 2D1, Rats, Wistar, enzyme analysis, dimethylnitrosamine demethylase, nonhuman, Rattus, Plant Extracts, plant seed, Rats, Urtica urens, aminopyrine n demethylase, cytochrome P450 2E1, Urtica, dwarf nettle, CYP2D1/2
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