Activity of delphinidin on microvascular damage models in rodents

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1992 English Publisher:WileyJournal:Phytotherapy Research, volume 6, pages 99-103 (issn: 0951-418X, eissn: 1099-1573,

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Authors: M. Conti; A. Cristoni; M. J. Magistretti;

doi: 10.1002/ptr.2650060210

Activity of delphinidin on microvascular damage models in rodents

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Abstract

AbstractDelphinidin chloride (IdB 1056) was found to possess a significant activity by the intraperitoneal and oral routes in different experimental models of microvascular damage. It antagonized the increase in skin capillary permeability induced by histamine in rats and rabbits, by bradykinin and hyaluronidase in rats and by xylol in mice. Significant increases in skin capillary resistance were observed after a 3‐day oral dosing in guinea‐pigs and rats. A significant enhancement in cutaneous wound healing rate was found with a 10‐day oral treatment in rats made locally ischaemic. Delphinidin showed a low acute toxicity by the oral route.

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