Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa
Copyright policy )Isolation and identification of cytotoxic compounds from the wood of Pinus resinosa
AbstractMethanol extracts of wood from Pinus resinosa were found to be selectively cytotoxic against human lung carcinoma cells, A549 (IC50 41 ± 6 µg/mL), human colorectal adenocarcinoma cells, DLD‐1 (IC50 47 ± 4 µg/mL) in comparison with healthy cells, WS1 (IC50 130 ± 11 µg/mL). Five known compounds were isolated and identified by 1H, 13C NMR spectroscopy and HR‐ESI‐MS mass spectrometry as, pinosylvin monomethyl ether (1), pinosylvin (2), pinosylvin dimethyl ether (3), pinobanksin (4) and (‐)‐norachelogenin (5). Compound 4 was isolated for the first time in P. resinosa. The cytotoxicity of compounds 1–5 was evaluated against A549, DLD‐1 and WS1. Compound 1 exhibited the strongest cytotoxicity against both tumor cell lines and the healthy cell line with an IC50 of 25 ± 4 µm for A549, 20 ± 1 µm for DLD‐1 and 34 ± 3 µm for WS1. Copyright © 2008 John Wiley & Sons, Ltd.
Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Cell Survival, Antineoplastic Agents, Pharmacologie, cytotoxic, Inhibitory Concentration 50, Phytoalexins, Cell Line, Tumor, Neoplasms, Stilbenes, Pinus resinosa, Chimie, Humans, Skin, Dose-Response Relationship, Drug, Plant Extracts, Methanol, Fibroblasts, Pinus, Wood, stilbene, Biologie et autres sciences connexes, Flavanones, Drug Screening Assays, Antitumor, bioassay-guided isolation
Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Cell Survival, Antineoplastic Agents, Pharmacologie, cytotoxic, Inhibitory Concentration 50, Phytoalexins, Cell Line, Tumor, Neoplasms, Stilbenes, Pinus resinosa, Chimie, Humans, Skin, Dose-Response Relationship, Drug, Plant Extracts, Methanol, Fibroblasts, Pinus, Wood, stilbene, Biologie et autres sciences connexes, Flavanones, Drug Screening Assays, Antitumor, bioassay-guided isolation
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