Anticancer activity of limonoid from Khaya senegalensis
Copyright policy )Anticancer activity of limonoid from Khaya senegalensis
AbstractTwo limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α‐dideacetylkhivorin (1) and 1‐O‐acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H‐1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF‐7, SiHa and Caco‐2 cells with IC50 values in the range of 0.07–0.14 µm (35–69 ppm) while compound 2 did not. Copyright © 2007 John Wiley & Sons, Ltd.
- University of South Carolina System United States
- University of South Carolina United States
- Clemson University United States
Limonins, Molecular Structure, Uterine Cervical Neoplasms, Breast Neoplasms, Antineoplastic Agents, Phytogenic, Inhibitory Concentration 50, Cell Line, Tumor, Colonic Neoplasms, Humans, Female, Meliaceae, Cell Proliferation, Phytotherapy
Limonins, Molecular Structure, Uterine Cervical Neoplasms, Breast Neoplasms, Antineoplastic Agents, Phytogenic, Inhibitory Concentration 50, Cell Line, Tumor, Colonic Neoplasms, Humans, Female, Meliaceae, Cell Proliferation, Phytotherapy
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