Flavonoids from ChineseViscum coloratum: antiarrhythmic efficacy and ionic mechanisms
Copyright policy )Flavonoids from ChineseViscum coloratum: antiarrhythmic efficacy and ionic mechanisms
Viscum coloratum flavonoids (VCF) have been demonstrated to produce a variety of biological actions. An accumulating line of evidence supported the view that VCF may exert protective effects on the cardiovascular system. The aim of the study was to assess the antiarrhythmic activity as well as the electrophysiological properties of VCF. The antiarrhythmic effects of VCF were observed in a rat model of arrhythmia induced by aconitine. VCF significantly and dose-dependently increased the dosage of aconitine required to induce the arrhythmia indexes. Electrophysiological experiment revealed that VCF shortened APD through inhibition of ICa-L.
- Harbin Medical University China (People's Republic of)
Flavonoids, Aconitine, Action Potentials, Arrhythmias, Cardiac, Rats, Random Allocation, Viscum, Animals, Myocytes, Cardiac, Calcium Channels, Rats, Wistar, Anti-Arrhythmia Agents, Drugs, Chinese Herbal
Flavonoids, Aconitine, Action Potentials, Arrhythmias, Cardiac, Rats, Random Allocation, Viscum, Animals, Myocytes, Cardiac, Calcium Channels, Rats, Wistar, Anti-Arrhythmia Agents, Drugs, Chinese Herbal
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!