Antiprotozoal activity of the constituents of Teloxys graveolens

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2003 English Publisher:WileyJournal:Phytotherapy Research, volume 17, pages 731-732 (issn: 0951-418X, eissn: 1099-1573,

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Authors: Fernando, Calzada; Claudia, Velázquez; Roberto, Cedillo-Rivera; Baldomero, Esquivel;

doi: 10.1002/ptr.1192

pmid: 12916068

Antiprotozoal activity of the constituents of Teloxys graveolens

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Abstract

AbstractAntiprotozoal activity‐guided fractionation of a methanol extract of the aerial parts of Teloxys graveolens led to the isolation of one coumarinic acid derivative, melilotoside, and five flavonoids, pinocembrine, pinostrobin, chrysin, narcissin and rutin. Among them, melilotoside exhibited the most potent activity toward Entamoeba histolytica and Giardia lamblia (IC50 12.5 and 16.8 µg/mL, respectively). Narcissin showed selectivity against E. histolytlica (IC50 17.2 µg/mL). The results support data for the traditional use of T. graveolens in some gastrointestinal diseases. Copyright © 2003 John Wiley & Sons, Ltd.

Related Organizations

Mexican Social Security Institute
Mexico
National Autonomous University of Mexico
Mexico
Centro Medico Nacional Siglo XXI
Mexico

Keywords

Giardiasis, Amaranthaceae, Entamoebiasis, Plant Extracts, Entamoeba histolytica, Antiprotozoal Agents, Plant Components, Aerial, Inhibitory Concentration 50, Parasitic Sensitivity Tests, Animals, Giardia lamblia, Phytotherapy

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