Antihyperglycaemic effect and acute toxicity of Securigera Securidaca L. seed extracts in mice
Copyright policy )Antihyperglycaemic effect and acute toxicity of Securigera Securidaca L. seed extracts in mice
AbstractThe antihyperglycaemic activity of a Securigera securidaca aqueous infusion and an ethanol maceration extract of seeds was studied in normoglycaemic, glucose‐induced hyperglycaemic and alloxan‐induced diabetic mice. The acute toxicity of the ethanol extract was more than that of the aqueous one. The phytochemical analysis showed that the seed extracts were rich in flavonoids. The intraperitoneal and oral administration of the aqueous and ethanol extracts significantly reduced blood glucose in alloxan‐induced diabetic mice. In normoglycaemic and glucose‐induced hyperglycaemic mice, the blood glucose levels were not significantly different from the control. Glibenclamide was not able to lower blood glucose in alloxan‐induced diabetic mice, while it significantly lowered the blood sugar in normoglycaemic mice. The results indicate that S. securidaca seed extracts significantly reduce blood glucose in alloxan‐induced diabetic mice by a mechanism different from that of sulfonylurea agents. Copyright © 2002 John Wiley & Sons, Ltd.
- Pharmaceutical Sciences Research Center Iran (Islamic Republic of)
- Mashhad University of Medical Sciences Iran (Islamic Republic of)
Blood Glucose, Male, Dose-Response Relationship, Drug, Plant Extracts, Administration, Oral, Fabaceae, Diabetes Mellitus, Experimental, Lethal Dose 50, Mice, Glucose, Hyperglycemia, Alloxan, Glyburide, Seeds, Animals, Hypoglycemic Agents, Injections, Intraperitoneal, Phytotherapy
Blood Glucose, Male, Dose-Response Relationship, Drug, Plant Extracts, Administration, Oral, Fabaceae, Diabetes Mellitus, Experimental, Lethal Dose 50, Mice, Glucose, Hyperglycemia, Alloxan, Glyburide, Seeds, Animals, Hypoglycemic Agents, Injections, Intraperitoneal, Phytotherapy
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