Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction
Copyright policy )Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction
Six all‐hydrocarbon‐stapled Cdt1 MBD‐derived peptides have been designed and synthesized to perturb the Cdt1–Mcm6 interaction, which is involved in DNA replication. Inconsistency between the helicity of the obtained peptidomimetics and their binding affinity has been observed. The helicity of 13‐amino acid stapled peptides increased, while their binding to Mcm6 was decreased. On the other hand, the 30‐amino acid stapled peptides exhibited decreased helicity but increased binding affinity. Copyright © 2015 European Peptide Society and John Wiley & Sons, Ltd.
- Hong Kong University of Science and Technology Hong Kong
- State Key Laboratory of Synthetic Chemistry Hong Kong
- The Hong Kong University of Science and Technology (Guangzhou) China (People's Republic of)
- University of Hong Kong China (People's Republic of)
- HONG KONG POLYTECHNIC UNIVERSITY China (People's Republic of)
Models, Molecular, Binding Sites, Cell Cycle Proteins, Minichromosome Maintenance Complex Component 6, Protein Structure, Secondary, Stapled peptides, Drug Design, Cdt1, Humans, Peptidomimetics, Peptides, Mcm6, Protein Binding
Models, Molecular, Binding Sites, Cell Cycle Proteins, Minichromosome Maintenance Complex Component 6, Protein Structure, Secondary, Stapled peptides, Drug Design, Cdt1, Humans, Peptidomimetics, Peptides, Mcm6, Protein Binding
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