Side chain‐to‐side chain cyclization by click reaction
Copyright policy )Side chain‐to‐side chain cyclization by click reaction
AbstractCuI‐catalyzed azide‐alkyne 1,3‐dipolar Huisgen's cycloaddition (CuAAC) is a click reaction that has drawn a lot of attention, in general, and in the field of peptide and protein sciences, in particular. Among several reported applications, the preparation of novel heterodetic cyclopeptides by an intramolecular side chain‐to‐side chain CuAAC, forming a 1,4‐disubstituted[1,2,3]triazolyl‐containing bridge, is of great interest. Herein, we provide a detailed protocol for the syntheses of model heterodetic cyclopeptides as a prototypical intramolecular CuAAC, using as a model a sequence derived from parathyroid hormone‐related protein. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.
- New York University Italy
- Brigham and Women's Faulkner Hospital United States
- University of Florence Italy
- Harvard University United States
click reaction; Huisgen’s cycloaddition; cyclopeptide; parathyroid hormone-related protein, Models, Molecular, Azides, Molecular Structure, Cyclization, Alkynes, Peptides, Cyclic, Catalysis, Copper
click reaction; Huisgen’s cycloaddition; cyclopeptide; parathyroid hormone-related protein, Models, Molecular, Azides, Molecular Structure, Cyclization, Alkynes, Peptides, Cyclic, Catalysis, Copper
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).37 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!