Correlations of the electrophysiological activity of neonicotinoids with their binding and insecticidal activities
Copyright policy )Correlations of the electrophysiological activity of neonicotinoids with their binding and insecticidal activities
AbstractThe electrophysiological actions of various neonicotinoids, including substituted benzyl derivatives, against recombinant Drosophila SAD/chicken β2 hybrid nicotinic acetylcholine receptor (nAChR) were measured to analyze the relationships between the in vivo (insecticidal) and in vitro (binding and agonist) activities. Most of the neonicotinoids tested were capable of inducing inward currents by activating the hybrid nAChRs expressed in Xenopus laevis oocytes, whereas some compounds had no agonist activity and only blocked the acetylcholine‐induced currents. Variations in the agonist activity were well correlated with those in the binding potency evaluated using [3H]imidacloprid as well as insecticidal activities. Copyright © 2003 Society of Chemical Industry
- Kindai University Japan
- Kyoto University Japan
Insecticides, Nicotine, Pyridines, Imidazoles, Receptors, Nicotinic, Bridged Bicyclo Compounds, Heterocyclic, Bungarotoxins, Nitro Compounds, Tritium, Binding, Competitive, Electrophysiology, Neonicotinoids, Xenopus laevis, Oocytes, Animals, Drosophila, Nicotinic Agonists, Algorithms
Insecticides, Nicotine, Pyridines, Imidazoles, Receptors, Nicotinic, Bridged Bicyclo Compounds, Heterocyclic, Bungarotoxins, Nitro Compounds, Tritium, Binding, Competitive, Electrophysiology, Neonicotinoids, Xenopus laevis, Oocytes, Animals, Drosophila, Nicotinic Agonists, Algorithms
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