Human factors and process safety management (PSM) have become key factors in preventing exposure to both hazardous materials and major accidents. Therefore, comprehensive process safety management is required to address all aspects of human factors. Currently, there are several‐process safety management models all of which have some weaknesses with respect to the control of human factors inherent in the process industry. Moreover, there is as yet no universally accepted process safety management model that treats process safety management as an integral part of the management system. Therefore, a need has arisen to integrate human factors and the existing frameworks and models into a single integrated management system to ensure a holistic approach of control and a continuous learning system. This article identifies the missing human factors in the current system and describes an integrated process safety management system (IPSMS) model drawn from screening all existing PSM frameworks, while integrating the Human Factors Analysis and Classification System (HFACS). The model, which adopts the PLAN, DO, CHECK, and ACT framework, also outlines an implementation strategy. We conclude that IPSMS provides both a theoretical and a practical framework with which to manage, measure and analyse process safety management systems. © 2017 American Institute of Chemical Engineers Process Process Saf Prog 37:67–85, 2018