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Proteins Structure Function and Bioinformatics
Article . 2021 . Peer-reviewed
License: CC BY
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Article . 2021
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Cryo‐EM targets in CASP14

Authors: Tristan Cragnolini; Andriy Kryshtafovych; Maya Topf;

Cryo‐EM targets in CASP14

Abstract

Abstract Structures of seven CASP14 targets were determined using cryo‐electron microscopy (cryo‐EM) technique with resolution between 2.1 and 3.8 Å. We provide an evaluation of the submitted models versus the experimental data (cryo‐EM density maps) and experimental reference structures built into the maps. The accuracy of models is measured in terms of coordinate‐to‐density and coordinate‐to‐coordinate fit. A‐posteriori refinement of the most accurate models in their corresponding cryo‐EM density resulted in structures that are close to the reference structure, including some regions with better fit to the density. Regions that were found to be less “refineable” correlate well with regions of high diversity between the CASP models and low goodness‐of‐fit to density in the reference structure.

Countries
United States, Germany
Keywords

Models, Molecular, model evaluation, 570, Bioinformatics, Protein Conformation, Mathematical sciences, Mathematical Sciences, Models, Sequence Analysis, Protein, Information and Computing Sciences, Research Articles, info:eu-repo/classification/ddc/570, electron microscopy, Protein, Cryoelectron Microscopy, Molecular, Computational Biology, Proteins, Biological Sciences, protein structure prediction, Biological sciences, CASP, cryo-EM, Sequence Analysis, Software

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    9
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Top 10%
Average
Top 10%
Green
hybrid