The ST pinch: A side chain‐to‐side chain hydrogen‐bonded motif
Copyright policy )The ST pinch: A side chain‐to‐side chain hydrogen‐bonded motif
AbstractThe ST Pinch is a 12‐membered hydrogen‐bonded motif (Ser/Thr‐Xaa‐Ser/Thr) involving the side chain oxygen atoms of two Ser/Thr residues. We identified the ST Pinch in 104 proteins in a database containing high‐resolution crystal structures. Conformational analysis of the ST Pinch in these proteins points to specific preferences for the Xaa residue and a high propensity of this residue to adopt positive φ angles. Our results suggest that this motif serves as a linker of secondary structural elements within proteins and is a new addition to the existing list of short hydrogen bond‐stabilized motifs in proteins. Proteins 2012;. © 2012 Wiley Periodicals, Inc.
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Models, Molecular, Protein Conformation, Amino Acid Motifs, Hydrogen Bonding, Amino Acids, Databases, Protein, Peptides
Models, Molecular, Protein Conformation, Amino Acid Motifs, Hydrogen Bonding, Amino Acids, Databases, Protein, Peptides
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