The type III secretion system needle, tip, and translocon

descriptionPublicationkeyboard_double_arrow_right Article 02 Aug 2019 English Publisher:WileyJournal:Protein Science, volume 28, pages 1,582-1,593 (issn: 0961-8368, eissn: 1469-896X,

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Authors: Supratim Dey; Amritangshu Chakravarty; Pallavi Guha Biswas; Roberto N. De Guzman;

doi: 10.1002/pro.3682

pmid: 31301256

pmc: PMC6699086

The type III secretion system needle, tip, and translocon

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Abstract

AbstractMany Gram‐negative bacteria pathogenic to plants and animals deploy the type III secretion system (T3SS) to inject virulence factors into their hosts. All bacteria that rely on the T3SS to cause infectious diseases in humans have developed antibiotic resistance. The T3SS is an attractive target for developing new antibiotics because it is essential in virulence, and part of its structural component is exposed on the bacterial surface. The structural component of the T3SS is the needle apparatus, which is assembled from over 20 different proteins and consists of a base, an extracellular needle, a tip, and a translocon. This review summarizes the current knowledge on the structure and assembly of the needle, tip, and translocon.

Related Organizations

University of Kansas
United States

Keywords

Models, Molecular, Bacterial Proteins, Virulence, Multiprotein Complexes, Drug Resistance, Bacterial, Gram-Negative Bacteria, Type III Secretion Systems, Animals, Humans

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