CTCF terminal segments are unstructured
Copyright policy )CTCF terminal segments are unstructured
AbstractThe human CCCTC‐binding factor, CTCF, organizes and regulates transcription of the genome by colocalizing distant DNA elements on the same and even different chromosomes. This protein consists of 11 zinc fingers flanked by polypeptide segments of unknown structure and function. We purified recombinant terminal fragments and observed that both are extended, monomeric, and predominantly consist of unordered content. We thus speculate that the role of the terminal extensions, and perhaps all of CTCF, is to act as a scaffold for the assembly of other proteins on a specific binding site.
- University of California, San Francisco United States
Repressor Proteins, CCCTC-Binding Factor, Binding Sites, Protein Conformation, Chromatography, Gel, Escherichia coli, Humans, Electrophoresis, Polyacrylamide Gel, Zinc Fingers, Recombinant Proteins
Repressor Proteins, CCCTC-Binding Factor, Binding Sites, Protein Conformation, Chromatography, Gel, Escherichia coli, Humans, Electrophoresis, Polyacrylamide Gel, Zinc Fingers, Recombinant Proteins
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