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Biomarkers in pediatrics: Children as biomarker orphans

descriptionPublicationkeyboard_double_arrow_right Article 29 Nov 2010Publisher:WileyJournal:PROTEOMICS – Clinical Applications, volume 4, pages 915-921 (issn: 1862-8346, eissn: 1862-8354,

Authors: Allen D. Everett; William J. Savage;

doi: 10.1002/prca.201000062

pmid: 21137032

Biomarkers in pediatrics: Children as biomarker orphans

- Summary
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Abstract

AbstractBiomarkers have enormous potential to improve patient care by establishing tests of diagnosis, prognosis, and treatment effects. Successfully translating a biomarker from discovery to clinical application demands high‐quality discovery research and high‐quality clinical studies for biomarker validation; however, there are additional challenges that face biomarker research in pediatrics. There are also additional characteristics of pediatric medicine that make biomarker research especially needed. This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research.

Related Organizations

Johns Hopkins University School of Medicine
United States
Johns Hopkins Medicine
United States

Keywords

Biomedical Research, Neonatal Screening, Reference Values, Infant, Newborn, Humans, Child, Prognosis, Biomarkers

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	32
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%