Eine vereinfachte Synthese von Methionin‐Enkephalin

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1978 English Publisher:WileyJournal:Journal für Praktische Chemie, volume 320, pages 963-966 (issn: 0021-8383,

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Authors: Günter Losse; Klaus‐Dieter Wehrstedt;

doi: 10.1002/prac.19783200610

Eine vereinfachte Synthese von Methionin‐Enkephalin

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Abstract

A Convenient Synthesis of Methionin‐EnkephalinAn efficient synthesis of methionin‐enkephalin has been developed by prolongation of the C‐terminal amino acid methylester using Boc‐Phe‐OHNomenklatur und Abkürzungen nach den Regeln der IUPAC‐IUB‐Commission on Bichemical Nomenclature: Hoppe‐Seyler's Z. physiol. Chem. 348, 256 (1967), J. Biol. Chem. 247, 977 (1972); weitere Abkürzungen: DCC = Dicyclohexylcarbodiimid, HOBt = 1‐Hydroxybenzotriazol, DMF = Dimethylformamid. , Boc‐Gly‐Gly‐OH and Boc‐Tyr‐OH.

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