
doi: 10.1002/pds.1014
pmid: 15386721
AbstractPurposeHerbal medicinal products (HMPs) are again highly popular. Their current popularity renders the assessment of their safety an urgent necessity.MethodNarrative review using examples only.ResultsConstituents of HMPs can be toxic and numerous examples of liver, kidney or other organ damage are on record. All HMPs contain a range of pharmacologically active constituents, and users of HMPs often combine HMPs with prescribed drugs. Thus herb–drug interactions are a real possibility. In most countries, HMPs are not submitted to stringent regulation and control. Thus unreliable quality can be a problem. In particular, this poses a risk when HMPs are contaminated (e.g. with heavy metals) or adulterated (e.g. with prescription drugs). The medical literature holds numerous examples for all of these scenarios and some are used in this article to illustrate the above points. As this area is grossly under‐researched, it is rarely possible to define the size of the problem.ConclusionsIt is concluded that the widespread notion of HMPs being inherently safe is naïve at best and dangerous at worst. More research is required to minimise the risk HMPs may pose to consumers' health. Copyright © 2004 John Wiley & Sons, Ltd.
Male, Pharmacoepidemiology, Herb-Drug Interactions, Humans, Middle Aged, Child, Hypericum, Drugs, Chinese Herbal, Kava
Male, Pharmacoepidemiology, Herb-Drug Interactions, Humans, Middle Aged, Child, Hypericum, Drugs, Chinese Herbal, Kava
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 111 | |
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| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 10% |
