Dereplication of pentacyclic triterpenoids in plants by GC‐EI/MS
Copyright policy )Dereplication of pentacyclic triterpenoids in plants by GC‐EI/MS
AbstractThree common plant‐derived pentacyclic triterpenoids, oleanolic acid (1), betulinic acid (2) and ursolic acid (3), have been found to exhibit moderate anti‐tubercular activity in a microplate alamar blue assay. In order to facilitate the discovery of novel anti‐tubercular leads with diverse chemical structures, a new and rapid GC‐EI/MS method was developed simultaneously and unambiguously to dereplicate 1–3 as their methyl esters with limits of detection of 25.6, 26.9 and 26.8 ng, respectively. Copyright © 2006 John Wiley & Sons, Ltd.
- University of Illinois at Chicago United States
- Pontifical Catholic University of Chile Chile
- Cubist Pharmaceuticals (United States) United States
- University of Arizona United States
- University of Kansas United States
570, Spectrometry, Mass, Electrospray Ionization, Lavanda (Planta), Chromatography, Gas, Tanacetum parthenium- Química, Molecular Structure, Biología, Antitubercular Agents, Tanacetum parthenium, Triterpenes, Lavandula, Valerian, 03 Salud y bienestar, Ursolic Acid, Triterpenos, 03 Good Health and Well-being, Agentes antituberculosos - Química, Oleanolic Acid, Betulinic Acid, Pentacyclic Triterpenes
570, Spectrometry, Mass, Electrospray Ionization, Lavanda (Planta), Chromatography, Gas, Tanacetum parthenium- Química, Molecular Structure, Biología, Antitubercular Agents, Tanacetum parthenium, Triterpenes, Lavandula, Valerian, 03 Salud y bienestar, Ursolic Acid, Triterpenos, 03 Good Health and Well-being, Agentes antituberculosos - Química, Oleanolic Acid, Betulinic Acid, Pentacyclic Triterpenes
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