Fetal programming and Wilms tumor
Copyright policy )Fetal programming and Wilms tumor
AbstractBackgroundThe “fetal programming” hypothesis has been evaluated in many adult diseases including cancer, but not for Wilms tumor. Wilms tumor has been related to high birthweight, but little is known about other growth metrics such as a baby's birth length, ponderal index, or placenta size, which can shed additional light on growth patterns.MethodsCases of Wilms tumor (N = 217) were taken from the Danish Cancer Registry, and controls (N = 4340) were randomly selected from the Population Register and matched to cases by sex and age. Linkage to the Medical Births Registry provided information on gestational factors and fetal growth measurements, while linkage to the Patient Register provided information on maternal and child health conditions.ResultsDespite having typically normal to higher birthweights, Wilms tumor cases had smaller placentas (≤540 g; odds ratio (OR) = 4.24; 95% confidence interval (CI), 1.84–9.78) and a lower placenta‐to‐birthweight ratio (OR = 1.81; 95% CI, 1.17–2.82, per 1 SD decrease). Small placentas were more common among Wilms cases without congenital anomalies (OR = 6.43; 95% CI, 1.95–21.21). Wilms tumor cases had a higher prevalence of high birthweight (>4000 g; OR = 1.57; 95% CI, 1.11–2.22), birth length 55 cm or longer (OR = 1.74; 95% CI, 1.09–2.78), and being large for gestational age (OR = 1.79; 95% CI, 1.08–2.96).ConclusionsOur study corroborates earlier studies showing associations with high birthweight and suggests associations between Wilms tumor and decreased placental size and low placenta‐to‐birthweight ratio.
- Aarhus University Denmark
- University of California, Los Angeles United States
- University of California United States
- UCLA Jonsson Comprehensive Cancer Center United States
Male, Kidney Disease, Reproductive health and childbirth (hrcs-hc), Placenta, Registries (mesh), fetal development, Reproductive health and childbirth, Birth Weight (mesh), Fetal Development, Clinical Research (rcdc), Pregnancy, Placenta (mesh), 1103 Clinical Sciences (for), Birth Weight, Registries, 32 Biomedical and Clinical Sciences (for-2020), Male (mesh), Kidney Disease (rcdc), Cancer, Pediatric, Cancer (rcdc), Humans (mesh), 3 Good Health and Well Being (sdg), Follow-Up Studies (mesh), 1112 Oncology and Carcinogenesis (for), Prognosis, Kidney Neoplasms, birthweight, 3213 Paediatrics (for-2020), nephroblastoma, Newborn (mesh), Female, Adult, Perinatal Period - Conditions Originating in Perinatal Period (rcdc), 3215 Reproductive Medicine (for-2020), placenta, Clinical Sciences, Oncology and Carcinogenesis, 610, Gestational Age, Wilms Tumor, Case-Control Studies (mesh), 1114 Paediatrics and Reproductive Medicine (for), Paediatrics and Reproductive Medicine, Conditions Affecting the Embryonic and Fetal Periods (rcdc), Rare Diseases (rcdc), Kidney Neoplasms (mesh), Rare Diseases, Clinical Research, 3211 Oncology and carcinogenesis (for-2020), Humans, Conditions Affecting the Embryonic and Fetal Periods, Oncology & Carcinogenesis, Pediatric (rcdc), Wilms Tumor (mesh), Biomedical and Clinical Sciences, Gestational Age (mesh), Infant, Newborn, Infant, Paediatrics, Perinatal Period - Conditions Originating in Perinatal Period, Prognosis (mesh), Newborn, Good Health and Well Being, Fetal Development (mesh), Pregnancy (mesh), Reproductive Medicine, Oncology & Carcinogenesis (science-metrix), Female (mesh), Case-Control Studies, Adult (mesh), body size, Follow-Up Studies
Male, Kidney Disease, Reproductive health and childbirth (hrcs-hc), Placenta, Registries (mesh), fetal development, Reproductive health and childbirth, Birth Weight (mesh), Fetal Development, Clinical Research (rcdc), Pregnancy, Placenta (mesh), 1103 Clinical Sciences (for), Birth Weight, Registries, 32 Biomedical and Clinical Sciences (for-2020), Male (mesh), Kidney Disease (rcdc), Cancer, Pediatric, Cancer (rcdc), Humans (mesh), 3 Good Health and Well Being (sdg), Follow-Up Studies (mesh), 1112 Oncology and Carcinogenesis (for), Prognosis, Kidney Neoplasms, birthweight, 3213 Paediatrics (for-2020), nephroblastoma, Newborn (mesh), Female, Adult, Perinatal Period - Conditions Originating in Perinatal Period (rcdc), 3215 Reproductive Medicine (for-2020), placenta, Clinical Sciences, Oncology and Carcinogenesis, 610, Gestational Age, Wilms Tumor, Case-Control Studies (mesh), 1114 Paediatrics and Reproductive Medicine (for), Paediatrics and Reproductive Medicine, Conditions Affecting the Embryonic and Fetal Periods (rcdc), Rare Diseases (rcdc), Kidney Neoplasms (mesh), Rare Diseases, Clinical Research, 3211 Oncology and carcinogenesis (for-2020), Humans, Conditions Affecting the Embryonic and Fetal Periods, Oncology & Carcinogenesis, Pediatric (rcdc), Wilms Tumor (mesh), Biomedical and Clinical Sciences, Gestational Age (mesh), Infant, Newborn, Infant, Paediatrics, Perinatal Period - Conditions Originating in Perinatal Period, Prognosis (mesh), Newborn, Good Health and Well Being, Fetal Development (mesh), Pregnancy (mesh), Reproductive Medicine, Oncology & Carcinogenesis (science-metrix), Female (mesh), Case-Control Studies, Adult (mesh), body size, Follow-Up Studies
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