AbstractWe describe three children who developed isolated but severe microangiopathic hemolytic anemia without other manifestations of hemolytic uremic syndrome (HUS) or thrombotic thrombocytopenic purpura (TTP). All three recovered without specific treatment. We propose that they represent a unique phenotype in the spectrum of TTP and HUS, which we term “hemolytic non‐uremic syndrome.” Pediatr Blood Cancer 2012; 59: 167–169. © 2011 Wiley Periodicals, Inc.