Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation
Copyright policy )Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation
AbstractAlthough Noonan syndrome (NS) is occasionally associated with embryonal solid tumors, there has been no report of hepatoblastoma in NS. We identified hepatoblastoma spreading into bilateral hepatic lobes in a 1‐month‐old NS patient with a heterozygous PTPN11 mutation (Asn308Asp). This finding suggests the potential relevance of constitutively activated RAS/MAPK signaling in the development of hepatoblastoma. Pediatr Blood Cancer 2008;50:1274–1276. © 2008 Wiley‐Liss, Inc.
Hepatoblastoma, Male, Heterozygote, Adolescent, Noonan Syndrome, Mutation, Missense, Infant, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Mutation, Humans, Germ-Line Mutation, Follow-Up Studies
Hepatoblastoma, Male, Heterozygote, Adolescent, Noonan Syndrome, Mutation, Missense, Infant, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Mutation, Humans, Germ-Line Mutation, Follow-Up Studies
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