Preclinical models of pancreatic ductal adenocarcinoma
Copyright policy )Preclinical models of pancreatic ductal adenocarcinoma
AbstractPancreatic ductal adenocarcinoma (PDA) is one of the most difficult human malignancies to treat. The 5‐year survival rate of PDA patients is 7% and PDA is predicted to become the second leading cancer‐related cause of death in the USA. Despite intensive efforts, the translation of findings in preclinical studies has been ineffective, due partially to the lack of preclinical models that faithfully recapitulate features of human PDA. Here, we review current preclinical models for human PDA (eg human PDA cell lines, cell line‐based xenografts and patient‐derived tumour xenografts). In addition, we discuss potential applications of the recently developed pancreatic ductal organoids, three‐dimensional culture systems and organoid‐based xenografts as new preclinical models for PDA. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
- University of California United States
- Cold Spring Harbor Laboratory United States
- Lustgarten Foundation United States
- University Medical Center Utrecht Netherlands
- Memorial Sloan Kettering Cancer Center United States
pancreatic cancer, Cell Culture Techniques, Drug Evaluation, Preclinical, Review, Mice, Pathology (science-metrix), 1103 Clinical Sciences (for), Pathology, Animals (mesh), 32 Biomedical and Clinical Sciences (for-2020), preclinical model, Cancer, Cancer (rcdc), Heterologous, Humans (mesh), Tumor, Pancreatic Cancer (rcdc), Research Support, Non-U.S. Gov't, Mice (mesh), Preclinical, 5.1 Pharmaceuticals, Pancreatic Ductal, Cell Culture Techniques (mesh), Development of treatments and therapeutic interventions, Tumor (mesh), Biotechnology, Digestive Diseases (rcdc), Carcinoma, Pancreatic Ductal, patient-derived tumour xenograft, organoid, Clinical Sciences, Transplantation, Heterologous, Biotechnology (rcdc), Cell Line, Rare Diseases (rcdc), Pancreatic Cancer, Rare Diseases, Research Support, N.I.H., Extramural, Cell Line, Tumor, Pancreatic Neoplasms (mesh), Journal Article, 3211 Oncology and carcinogenesis (for-2020), Animals, Humans, Heterologous (mesh), Preclinical (mesh), Animal (mesh), Pancreatic Ductal (mesh), Transplantation, Animal, 4.1 Discovery and preclinical testing of markers and technologies (hrcs-rac), Carcinoma, Cancer (hrcs-hc), 3202 Clinical sciences (for-2020), Neoplasm Transplantation (mesh), Pancreatic Neoplasms, Disease Models, Animal, 3211 Oncology and Carcinogenesis (for-2020), Disease Models, Drug Evaluation, Digestive Diseases, Research Support, U.S. Gov't, Non-P.H.S., Neoplasm Transplantation
pancreatic cancer, Cell Culture Techniques, Drug Evaluation, Preclinical, Review, Mice, Pathology (science-metrix), 1103 Clinical Sciences (for), Pathology, Animals (mesh), 32 Biomedical and Clinical Sciences (for-2020), preclinical model, Cancer, Cancer (rcdc), Heterologous, Humans (mesh), Tumor, Pancreatic Cancer (rcdc), Research Support, Non-U.S. Gov't, Mice (mesh), Preclinical, 5.1 Pharmaceuticals, Pancreatic Ductal, Cell Culture Techniques (mesh), Development of treatments and therapeutic interventions, Tumor (mesh), Biotechnology, Digestive Diseases (rcdc), Carcinoma, Pancreatic Ductal, patient-derived tumour xenograft, organoid, Clinical Sciences, Transplantation, Heterologous, Biotechnology (rcdc), Cell Line, Rare Diseases (rcdc), Pancreatic Cancer, Rare Diseases, Research Support, N.I.H., Extramural, Cell Line, Tumor, Pancreatic Neoplasms (mesh), Journal Article, 3211 Oncology and carcinogenesis (for-2020), Animals, Humans, Heterologous (mesh), Preclinical (mesh), Animal (mesh), Pancreatic Ductal (mesh), Transplantation, Animal, 4.1 Discovery and preclinical testing of markers and technologies (hrcs-rac), Carcinoma, Cancer (hrcs-hc), 3202 Clinical sciences (for-2020), Neoplasm Transplantation (mesh), Pancreatic Neoplasms, Disease Models, Animal, 3211 Oncology and Carcinogenesis (for-2020), Disease Models, Drug Evaluation, Digestive Diseases, Research Support, U.S. Gov't, Non-P.H.S., Neoplasm Transplantation
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