Preclinical models of pancreatic ductal adenocarcinoma
Copyright policy )Preclinical models of pancreatic ductal adenocarcinoma
AbstractPancreatic ductal adenocarcinoma (PDA) is one of the most difficult human malignancies to treat. The 5‐year survival rate of PDA patients is 7% and PDA is predicted to become the second leading cancer‐related cause of death in the USA. Despite intensive efforts, the translation of findings in preclinical studies has been ineffective, due partially to the lack of preclinical models that faithfully recapitulate features of human PDA. Here, we review current preclinical models for human PDA (eg human PDA cell lines, cell line‐based xenografts and patient‐derived tumour xenografts). In addition, we discuss potential applications of the recently developed pancreatic ductal organoids, three‐dimensional culture systems and organoid‐based xenografts as new preclinical models for PDA. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
- Lustgarten Foundation United States
- Royal Netherlands Academy of Arts and Sciences (KNAW) Netherlands
- Memorial Sloan Kettering Cancer Center United States
- University of California, San Francisco United States
- University Medical Center Utrecht Netherlands
patient-derived tumour xenograft, organoid, Clinical Sciences, pancreatic cancer, Transplantation, Heterologous, Cell Culture Techniques, Drug Evaluation, Preclinical, Review, Cell Line, Pancreatic Cancer, Mice, Rare Diseases, Research Support, N.I.H., Extramural, Cell Line, Tumor, Pathology, Journal Article, Animals, Humans, preclinical model, Cancer, Transplantation, Heterologous, Tumor, Animal, Research Support, Non-U.S. Gov't, Carcinoma, Preclinical, Pancreatic Neoplasms, Disease Models, Animal, 5.1 Pharmaceuticals, Pancreatic Ductal, Disease Models, Drug Evaluation, Development of treatments and therapeutic interventions, Digestive Diseases, Research Support, U.S. Gov't, Non-P.H.S., Neoplasm Transplantation, Biotechnology, Carcinoma, Pancreatic Ductal
patient-derived tumour xenograft, organoid, Clinical Sciences, pancreatic cancer, Transplantation, Heterologous, Cell Culture Techniques, Drug Evaluation, Preclinical, Review, Cell Line, Pancreatic Cancer, Mice, Rare Diseases, Research Support, N.I.H., Extramural, Cell Line, Tumor, Pathology, Journal Article, Animals, Humans, preclinical model, Cancer, Transplantation, Heterologous, Tumor, Animal, Research Support, Non-U.S. Gov't, Carcinoma, Preclinical, Pancreatic Neoplasms, Disease Models, Animal, 5.1 Pharmaceuticals, Pancreatic Ductal, Disease Models, Drug Evaluation, Development of treatments and therapeutic interventions, Digestive Diseases, Research Support, U.S. Gov't, Non-P.H.S., Neoplasm Transplantation, Biotechnology, Carcinoma, Pancreatic Ductal
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