The role of Kaposi sarcoma‐associated herpesvirus in the pathogenesis of Kaposi sarcoma

descriptionPublicationkeyboard_double_arrow_right Article 11 Dec 2014 English Publisher:WileyJournal:The Journal of Pathology, volume 235, pages 368-380 (issn: 0022-3417, eissn: 1096-9896,

Copyright policy )Funded by:DFG | unidentified

Authors: Silvia, Gramolelli; Thomas F, Schulz;

doi: 10.1002/path.4441

pmid: 25212381

The role of Kaposi sarcoma‐associated herpesvirus in the pathogenesis of Kaposi sarcoma

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Abstract

AbstractKaposi sarcoma (KS) is an unusual vascular tumour caused by an oncogenic‐herpesvirus, Kaposi sarcoma‐associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV 8). KS lesions are characterized by an abundant inflammatory infiltrate, the presence of KSHV‐infected endothelial cells that show signs of aberrant differentiation, as well as faulty angiogenesis/ vascularization. Here we discuss the molecular mechanisms that lead to the development of these histological features of KS, with an emphasis on the viral proteins that are responsible for their development. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Related Organizations

German Center for Infection Research
Germany
Hannover Medical School
Germany

Keywords

Skin Neoplasms, Neovascularization, Pathologic, Virulence, Endothelial Cells, Cell Differentiation, Herpesviridae Infections, Cell Transformation, Viral, Risk Factors, Herpesvirus 8, Human, Host-Pathogen Interactions, Animals, Humans, Sarcoma, Kaposi, Cell Proliferation

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