AbstractEnhanced transformation field analysis (E‐TFA), recently proposed for reduced‐order modeling, is here formulated for and applied to multiscale analysis. The approach is able to reproduce a highly complex nonlinear macroscale behavior, resulting from a microstructure with cohesive interfaces embedded in an elasto‐plastic bulk. E‐TFA features a consistent tangent matrix in its solution procedure, which enables a straightforward definition of the upscaled tangent stiffness tensor. Numerical tests show that, compared to FE, the proposed approach yields accurate solutions at a lower computational cost.