AbstractParallel imaging may be applied to cancel ghosts caused by a variety of distortion mechanisms, including distortions such as off‐resonance or local flow, which are space variant. Phased array combining coefficients may be calculated that null ghost artifacts at known locations based on a constrained optimization, which optimizes SNR subject to the nulling constraint. The resultant phased array ghost elimination (PAGE) technique is similar to the method known as sensitivity encoding (SENSE) used for accelerated imaging; however, in this formulation is applied to full field‐of‐view (FOV) images. The phased array method for ghost elimination may result in greater flexibility in designing acquisition strategies. For example, in multi‐shot EPI applications ghosts are typically mitigated by the use of an interleaved phase encode acquisition order. An alternative strategy is to use a sequential, non‐interleaved phase encode order and cancel the resultant ghosts using PAGE parallel imaging. Cancellation of ghosts by means of phased array processing makes sequential, non‐interleaved phase encode acquisition order practical, and permits a reduction in repetition time, TR, by eliminating the need for echo‐shifting. Sequential, non‐interleaved phase encode order has benefits of reduced distortion due to off‐resonance, in‐plane flow and EPI delay misalignment. Furthermore, the use of EPI with PAGE has inherent fat‐water separation and has been used to provide off‐resonance correction using a technique referred to as lipid elimination with an echo‐shifting N/2‐ghost acquisition (LEENA), and may further generalized using the multi‐point Dixon method. Other applications of PAGE include cancelling ghosts which arise due to amplitude or phase variation during the approach to steady state. Parallel imaging requires estimates of the complex coil sensitivities. In vivo estimates may be derived by temporally varying the phase encode ordering to obtain a full k‐space dataset in a scheme similar to the autocalibrating TSENSE method. This scheme is a generalization of the UNFOLD method used for removing aliasing in undersampled acquisitions. The more general scheme may be used to modulate each EPI ghost image to a separate temporal frequency as described in this paper. Copyright © 2006 John Wiley & Sons, Ltd.