Running endurance abnormality in mdx mice
Copyright policy )Running endurance abnormality in mdx mice
AbstractThe mdx mouse lacks dystrophin and has histological features of Duchenne muscular dystrophy but little weakness in the first year of life. We report here an early deficit in voluntary wheel running, as assayed with a computerized wheel. All mdx mice showed an intermittent running pattern, in contrast to the continuous running seen in controls. The average continuous running time differed significantly between mdx and control mice at all ages tested (5–21 weeks). This assay is noninvasive, has the advantage of unbiased automatic data collection, and should be useful for quantifying the mdx deficit in therapeutic studies. © 2002 John Wiley & Sons, Inc. Muscle Nerve 25: 207–211, 2002 DOI 10.1002/mus.10021
- University of Pennsylvania United States
- National Institute of Health Pakistan
- Showa University Japan
- National Institutes of Health United States
- National Institute of Neurological Disorders and Stroke United States
Male, Aging, Time Factors, Motor Activity, Mice, Inbred C57BL, Mice, Animals, Newborn, Reference Values, Mice, Inbred mdx, Physical Endurance, Animals, Female
Male, Aging, Time Factors, Motor Activity, Mice, Inbred C57BL, Mice, Animals, Newborn, Reference Values, Mice, Inbred mdx, Physical Endurance, Animals, Female
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