PurposeTo implement 3D magnetic resonance fingerprinting (MRF) with quadratic RF phase (qRF‐MRF) for simultaneous quantification of T1, T2, ΔB0, and .Methods3D MRF data with effective undersampling factor of 3 in the slice direction were acquired with quadratic RF phase patterns for T1, T2, and sensitivity. Quadratic RF phase encodes the off‐resonance by modulating the on‐resonance frequency linearly in time. Transition to 3D brings practical limitations for reconstruction and dictionary matching because of increased data and dictionary sizes. Randomized singular value decomposition (rSVD)‐based compression in time and reduction in dictionary size with a quadratic interpolation method are combined to be able to process prohibitively large data sets in feasible reconstruction and matching times.ResultsAccuracy of 3D qRF‐MRF maps in various resolutions and orientations are compared to 3D fast imaging with steady‐state precession (FISP) for T1 and T2 contrast and to 2D qRF‐MRF for contrast and ΔB0. The precision of 3D qRF‐MRF was 1.5‐2 times higher than routine clinical scans. 3D qRF‐MRF ΔB0 maps were further processed to highlight the susceptibility contrast.ConclusionNatively co‐registered 3D whole brain T1, T2, , ΔB0, and QSM maps can be acquired in as short as 5 min with 3D qRF‐MRF.