PurposeFlexibility in slice prescription is critical for precise motion monitoring during MR‐guided therapies. Adding more slices to improve spatial coverage during rapid 2D cine imaging often hampers temporal resolution. This work describes a framework to simultaneously acquire multiple arbitrarily oriented slices which share a common frequency encoding axis. This framework allows for higher frame rates for a given number of slices compared to conventional interleaved‐slice multi‐orientation cine imaging.Theory and MethodsA framework to calculate zeroth gradient moments to be played out between sequentially excited slices with multiple orientations is described here. Experiments were performed in phantom, and in vivo in the head/neck and abdomen of patients.ResultsImages arbitrarily rotated relative to one another were successfully obtained in phantom and in vivo. Simultaneous multi‐orientation (SMO) images were also acquired with additional in‐plane acceleration to demonstrate the capability of this method to rapidly image objects moving with physiological motion.ConclusionsThe technical feasibility of the generalized SMO imaging framework was tested in this study. It shows promise for continued development for motion monitoring during MR‐guided therapies.