Characterization of secretory leukocyte protease inhibitor as an inhibitor of implantation serine proteinases
Copyright policy )Characterization of secretory leukocyte protease inhibitor as an inhibitor of implantation serine proteinases
AbstractWe have recently identified and characterized twoimplantationserineproteinase genes, ISP1 and ISP2, which give rise to a dimeric proteinase, ISP that facilitates embryo invasion during peri‐implantation period. As many proteinases have cognate serpins that regulate their proteolytic activity, we have been investigating anti‐tryptases, expressed during this window of implantation. Here, we report the differential expression of secretory leukocyte protease inhibitor (SLPI) in uterine endometrium around the implantation period. The co‐localization of SLPI and ISP suggests the possibility that SLPI is an ISP serpin and that expression of SLPI may lead to a reduction in ISP activity. The expression of SLPI is down regulated during the window of embryo‐uterine receptivity. Our results are consistent with a model suggesting that the drop in SLPI expression may help to refine the opening of the window of implantation, by allowing the proteolytic activity of embryo invasive serine proteinases such as the ISPs. Mol. Reprod. Dev. 75: 1136–1142, 2008. © 2007 Wiley‐Liss, Inc.
- University of Calgary Canada
Serine Proteinase Inhibitors, Reverse Transcriptase Polymerase Chain Reaction, Serine Endopeptidases, Uterus, Vesicular Transport Proteins, Membrane Proteins, Mice, Inbred Strains, Mice, Pregnancy, Animals, RNA, Female, Secretory Leukocyte Peptidase Inhibitor, Embryo Implantation, DNA Primers
Serine Proteinase Inhibitors, Reverse Transcriptase Polymerase Chain Reaction, Serine Endopeptidases, Uterus, Vesicular Transport Proteins, Membrane Proteins, Mice, Inbred Strains, Mice, Pregnancy, Animals, RNA, Female, Secretory Leukocyte Peptidase Inhibitor, Embryo Implantation, DNA Primers
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