Biophysical aspects of cyclodextrin interaction with paraoxon

descriptionPublicationkeyboard_double_arrow_right Article 19 Dec 2013 English Publisher:WileyJournal:Magnetic Resonance in Chemistry, volume 52, pages 111-114 (issn: 0749-1581, eissn: 1097-458X,

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Authors: Sunil-Datta, Soni; Jayendra B, Bhonsle; Gregory E, Garcia;

doi: 10.1002/mrc.4036

pmid: 24357355

Biophysical aspects of cyclodextrin interaction with paraoxon

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Abstract

Cyclodextrins are torus‐shaped polymers of glucose that can bind organophosphorous compounds such as nerve agents and pesticides. We demonstrate here that cyclodextrin can bind up to two paraoxon molecules with a Kav of 6775 M‐1. Molecular modeling shows that the paraoxon appears to bind in polar opposite orientation and have an average binding energy of −89 Kcals/mol. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

Keywords

Models, Molecular, Cyclodextrins, Magnetic Resonance Spectroscopy, Molecular Structure, Reference Standards, Paraoxon

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