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Medical Physics
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Medical Physics
Article . 2020 . Peer-reviewed
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Medical Physics
Article . 2021
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Statistical characterization of the linear attenuation coefficient in polychromatic CT scans

Authors: Gonzalo, Vegas; Raúl, San José Estépar;

Statistical characterization of the linear attenuation coefficient in polychromatic CT scans

Abstract

PurposeTo provide a unifying statistical model that characterizes the integrated x‐ray intensity at the detector after logarithmic transformation and can be extended to the characterization of computed tomography (CT) numbers in the reconstructed image.MethodsWe study the statistical characteristics of polyenergetic x‐ray beams in the detector. Firstly, we consider the characterization of the integrated x‐ray intensity at the detector through a probabilistic model (compound Poisson) that describes its statistics. We analyze its properties and derive the probabilistic distribution after the logarithmic transformation analytically. Finally, we propose a more tractable probabilistic distribution with the same features observed in the characterization, the noncentral Gamma (nc‐Gamma). This distribution exhibits desirable properties for the statistical characterization across the reconstruction process. We assess the assumptions adopted in the derivation of the statistical models throughout Monte Carlo simulations and validate them with a water phantom and a lung phantom acquired in a Siemens clinical CT scan. We evaluate the statistical similarities between the theoretical distribution and the nc‐Gamma using a power analysis with a Kolmogorov–Smirnov test for a 95% confidence level.ResultsThe Kolmogorov–Smirnov goodness‐of‐fit test obtained for the Monte Carlo simulation shows an extremely high agreement between the empirical distribution of the post‐logarithmic‐integrated x‐ray intensity and the nc‐Gamma. The experimental validation performed with both phantoms confirmed the excellent match between the theoretical distribution, the proposed nc‐Gamma, and sample distributions in all situations.ConclusionWe derive an analytical model describing the post‐log distribution of the linear attenuation coefficient in the sensor for polychromatic CT scans. We also demonstrate that the nc‐Gamma distribution approximates well the theoretical distribution. This distribution also approximates well the CT numbers after reconstruction since it naturally extends across linear operations involved in filtered back projection reconstructions. This probabilistic model may provide the analytical foundation to define new likelihood‐based reconstruction methodologies for polychromatic scans.

Keywords

Likelihood Functions, Phantoms, Imaging, Image Processing, Computer-Assisted, Radionuclide Imaging, Tomography, X-Ray Computed, Monte Carlo Method, Algorithms

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Top 10%
Average
Average
bronze