Regulatory dendritic cells modulate immune responses via induction of T‐cell apoptotic death
Copyright policy )Regulatory dendritic cells modulate immune responses via induction of T‐cell apoptotic death
AbstractWe describe a regulatory lymphoid dendritic cell (LDC) population propagated from mouse liver nonparenchymal cells (NPC) in IL‐3 and anti‐CD40 monoclonal antibody that are phenotypically mature, and induce T‐cell hyporesponsiveness by promoting T‐cell apoptotic death, which is partially caspase‐dependent, but is unlikely to be mediated by soluble factor(s). In vivo administration of liver LDC significantly prolonged the survival of vascularized cardiac allografts in an alloantigen‐specific manner. This is associated with enhanced T‐cell death in secondary lymphoid organs. © 2006 Wiley‐Liss, Inc. Microsurgery 26: 21–24, 2006.
- University of Pittsburgh United States
- University of Pittsburgh Medical Center United States
Male, T-Lymphocytes, Graft Survival, Cell Culture Techniques, Apoptosis, Mice, Inbred Strains, Dendritic Cells, Mice, Liver, In Situ Nick-End Labeling, Animals, Heart Transplantation, Leukocyte Common Antigens
Male, T-Lymphocytes, Graft Survival, Cell Culture Techniques, Apoptosis, Mice, Inbred Strains, Dendritic Cells, Mice, Liver, In Situ Nick-End Labeling, Animals, Heart Transplantation, Leukocyte Common Antigens
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