FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder
Copyright policy )FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder
ABSTRACTBackgroundIdiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD‐related pattern were each associated with increased risk of conversion to PD. The objective of this study was to study the relationship between the PD‐related pattern, dopamine transporter binding, and olfaction in idiopathic REM sleep behavior disorder.MethodsIn this cross‐sectional study, 21 idiopathic REM sleep behavior disorder subjects underwent 18F‐fluorodeoxyglucose PET, dopamine transporter imaging, and olfactory testing. For reference, we included 18F‐fluorodeoxyglucose PET data of 19 controls, 20 PD patients, and 22 patients with dementia with Lewy bodies. PD‐related pattern expression z‐scores were computed from all PET scans.ResultsPD‐related pattern expression was higher in idiopathic REM sleep behavior disorder subjects compared with controls (P = 0.048), but lower compared with PD (P = 0.001) and dementia with Lewy bodies (P < 0.0001). PD‐related pattern expression was higher in idiopathic REM sleep behavior disorder subjects with hyposmia and in subjects with an abnormal dopamine transporter scan (P < 0.05, uncorrected).ConclusionPD‐related pattern expression, dopamine transporter binding, and olfaction may provide complementary information for predicting phenoconversion. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
- Helmholtz Zentrum München Germany
- Amsterdam UMC Netherlands
- Aachen University Germany
- University of Amsterdam Netherlands
- University of Gronigen Netherlands
18 F-fdg-pet ; Dopamine Transporter I-fp-cit Spect 123 ; Idiopathic Rem Sleep Behavior Disorder ; Olfaction ; Parkinson's Disease-related Pattern, Lewy Body Disease, Male, Parkinson Disease/diagnostic imaging, METABOLIC NETWORK ACTIVITY, idiopathic REM sleep behavior disorder, 610, REM Sleep Behavior Disorder, DIAGNOSIS, dopamine transporter I-FP-CIT SPECT, Olfaction Disorders, PARKINSONS-DISEASE, NEURODEGENERATIVE DISEASE, Fluorodeoxyglucose F18, Humans, Olfaction Disorders/diagnostic imaging, Parkinson's disease-related pattern, Tomography, info:eu-repo/classification/ddc/610, Aged, Psychiatric Status Rating Scales, Tomography, Emission-Computed, Single-Photon, Analysis of Variance, Dopamine Plasma Membrane Transport Proteins, ABNORMALITIES, DEMENTIA, Parkinson Disease, Lewy Body Disease/diagnostic imaging, Middle Aged, LEWY BODIES, DYSFUNCTION, BRAIN NETWORKS, F-FDG-PET, Cross-Sectional Studies, F-18-FDG-PET, dopamine transporter I-123-FP-CIT SPECT, Positron-Emission Tomography, REM Sleep Behavior Disorder/complications, Brief Reports, Female, Emission-Computed, Dopamine Plasma Membrane Transport Proteins/metabolism, olfaction, Single-Photon
18 F-fdg-pet ; Dopamine Transporter I-fp-cit Spect 123 ; Idiopathic Rem Sleep Behavior Disorder ; Olfaction ; Parkinson's Disease-related Pattern, Lewy Body Disease, Male, Parkinson Disease/diagnostic imaging, METABOLIC NETWORK ACTIVITY, idiopathic REM sleep behavior disorder, 610, REM Sleep Behavior Disorder, DIAGNOSIS, dopamine transporter I-FP-CIT SPECT, Olfaction Disorders, PARKINSONS-DISEASE, NEURODEGENERATIVE DISEASE, Fluorodeoxyglucose F18, Humans, Olfaction Disorders/diagnostic imaging, Parkinson's disease-related pattern, Tomography, info:eu-repo/classification/ddc/610, Aged, Psychiatric Status Rating Scales, Tomography, Emission-Computed, Single-Photon, Analysis of Variance, Dopamine Plasma Membrane Transport Proteins, ABNORMALITIES, DEMENTIA, Parkinson Disease, Lewy Body Disease/diagnostic imaging, Middle Aged, LEWY BODIES, DYSFUNCTION, BRAIN NETWORKS, F-FDG-PET, Cross-Sectional Studies, F-18-FDG-PET, dopamine transporter I-123-FP-CIT SPECT, Positron-Emission Tomography, REM Sleep Behavior Disorder/complications, Brief Reports, Female, Emission-Computed, Dopamine Plasma Membrane Transport Proteins/metabolism, olfaction, Single-Photon
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