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Essential pitfalls in “essential” tremor

Authors: Espay, Alberto J; Lang, Anthony E.; Erro, Roberto; Merola, Aristide; Fasano, Alfonso; BERARDELLI, Alfredo; Bhatia, Kailash P.;

Essential pitfalls in “essential” tremor

Abstract

ABSTRACTAlthough essential tremor has been considered the most common movement disorder, it has largely remained a diagnosis of exclusion: many tremor and nontremor features must be absent for the clinical diagnosis to stand. The clinical features of “essential tremor” overlap with or may be part of other tremor disorders and, not surprisingly, this prevalent familial disorder has remained without a gene identified, without a consistent natural history, and without an acceptable pathology or pathophysiologic underpinning. The collective evidence suggests that under the rubric of essential tremor there exists multiple unique diseases, some of which represent cerebellar dysfunction, but for which there is no intrinsic “essence” other than a common oscillatory behavior on posture and action. One approach may be to use the term essential tremor only as a transitional node in the deep phenotyping of tremor disorders based on historical, phenomenological, and neurophysiological features to facilitate its etiologic diagnosis or serve for future gene‐ and biomarker‐discovery efforts. This approach deemphasizes essential tremor as a diagnostic entity and facilitates the understanding of the underlying disorders to develop biologically tailored diagnostic and therapeutic strategies. © 2017 International Parkinson and Movement Disorder Society

Countries
Italy, United Kingdom
Keywords

biomarkers; essential tremor; nomenclature; tremor; Essential Tremor; Humans; Neurology; Neurology (clinical), Essential Tremor, biomarkers; essential tremor; nomenclature; tremor, Humans, nomenclature, essential tremor, tremor, Biomarkers, essential tremor; tremor; biomarkers; nomenclature

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    Top 1%
    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
86
Top 1%
Top 10%
Top 1%
bronze