Variable number tandem repeats in dopamine receptor D4 in Tourette's syndrome
Copyright policy )Variable number tandem repeats in dopamine receptor D4 in Tourette's syndrome
AbstractBackgroundWe attempted to clarify the association between dopamine receptor D4 (DRD4) 48‐bp variable number of tandem repeats (VNTR) polymorphism and Tourette's syndrome.MethodsThe DRD4 48‐bp VNTR polymorphism was genotyped in 291 Tourette's syndrome patients (including 218 trios) and 405 controls. Chi‐square and transmission disequilibrium test analysis were used to compare genetic distributions. We retrieved related studies in a meta‐analysis to clarify the role of 2‐repeat and 4‐repeat alleles in the pathogenesis.ResultsObvious genotype and allele distribution differences were observed between patients and healthy controls for both 2‐repeat and 4‐repeat alleles. This was verified using transmission disequilibrium test analysis. Meta‐analysis showed strong associations in both the total population and the Asian population.ConclusionsThe DRD4 48‐bp VNTR polymorphism appears to be associated with Tourette's syndrome, with the 2‐repeat allele performing a protective role and the 4‐repeat allele a nonprotective role in the genesis of the disease. © 2014 International Parkinson and Movement Disorder Society
- Qingdao Binhai University China (People's Republic of)
- World Health Organization Switzerland
- Affiliated Hospital of Qingdao University China (People's Republic of)
- Qingdao University China (People's Republic of)
Family Health, Male, Adolescent, Genotype, Receptors, Dopamine D4, Minisatellite Repeats, Young Adult, Gene Frequency, Meta-Analysis as Topic, Case-Control Studies, Child, Preschool, Humans, Female, Genetic Predisposition to Disease, Child, Tourette Syndrome
Family Health, Male, Adolescent, Genotype, Receptors, Dopamine D4, Minisatellite Repeats, Young Adult, Gene Frequency, Meta-Analysis as Topic, Case-Control Studies, Child, Preschool, Humans, Female, Genetic Predisposition to Disease, Child, Tourette Syndrome
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