H1/H1 genotype influences symptom severity in corticobasal syndrome
Copyright policy )H1/H1 genotype influences symptom severity in corticobasal syndrome
AbstractWe evaluated 38 consecutive patients with corticobasal syndrome to determine if inheritance of the H1/H1 genotype influences age at onset and disease severity and if Apolipoprotein E e4 increases the risk of cognitive disturbances. Inheritance of the H1/H1 genotype was associated with severity of motor function, but did not affect age at onset or cognition. There was a trend toward shorter survival in the H1/H1 group, but this study was underpowered to test influence on survival, even though it served to estimate the sample size for future studies. ApoE inheritance did not influence cognition. © 2009 Movement Disorder Society
- Mayo Clinic United States
- University of Louisville United States
- Eli Lilly (United States) United States
Male, Genotype, Apolipoprotein E4, tau Proteins, Syndrome, Middle Aged, Severity of Illness Index, Dystonia, Gene Frequency, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Age of Onset, Psychomotor Disorders, Mental Status Schedule
Male, Genotype, Apolipoprotein E4, tau Proteins, Syndrome, Middle Aged, Severity of Illness Index, Dystonia, Gene Frequency, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Age of Onset, Psychomotor Disorders, Mental Status Schedule
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).6 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!