AbstractBackgroundLaser tissue welding (LTW) is a novel method of surgical wound closure by the use of laser radiation to induce fusion of the biological tissues. Molecular dynamics associated with LTW is a result of thermal and non‐thermal mechanisms.ObjectivesThis research focuses exclusively on better heat management to reduce thermal damage of tissues in LTW using a near infrared laser radiation.MethodsAn infrared continuous‐wave (CW) laser radiation at 1,450 nm wavelength corresponding to the absorption band from combination vibrational modes of water is used to weld together ex vivo porcine aorta.ResultsIn these studies we measured the optimal laser power and scan speed, for better tensile strength of the weld and lesser tissue dehydration. Significant amount of water loss from the welded tissue results in cellular death and tissue buckling. Various thermally conductive optical cover windows were used as heat sinks to reduce thermal effects during LTW for the dissipation of the heat. The optimal use of the method prevents tissue buckling and minimizes the water loss. Diamond, sapphire, BK7, fused silica, and IR quartz transparent optical cover windows were tested.ConclusionsThe data from this study suggests that IR‐quartz as the material with optimal thermal conductivity is ideal for laser welding of the porcine aorta. Lasers Surg. Med. 43:991–997, 2011. © 2011 Wiley Periodicals, Inc.