The Prognostic Role of Programmed Death‐Ligand 1 in Nasopharyngeal Carcinoma

descriptionPublicationkeyboard_double_arrow_right Article 29 Feb 2020 English Publisher:WileyJournal:The Laryngoscope, volume 130, pages 2,598-2,606 (issn: 0023-852X, eissn: 1531-4995,

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Authors: Michael Wotman; Saori W. Herman; Peter Costantino; Tristan Tham;

doi: 10.1002/lary.28523

pmid: 32112431

The Prognostic Role of Programmed Death‐Ligand 1 in Nasopharyngeal Carcinoma

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Abstract

ObjectivesProgrammed death‐ligand 1 (PD‐L1) is an immune checkpoint protein that may be a useful prognostic biomarker in nasopharyngeal cancer (NPC). The purpose of this systematic review and meta‐analysis was to investigate the relationship between PD‐L1 expression and survival in NPC.MethodsPubMed, Cochrane, Embase, Scopus, and Web of Science were searched from inception to present. A predefined inclusion and exclusion criteria were used to select articles. Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled for overall survival (OS), disease‐free survival (DFS), and disease metastasis‐free survival (DMFS).ResultsEleven studies published from 2014 to 2018 were included, with 1,356 total participants. PD‐L1 expression was not associated with OS (HR = 1.10, 95% CI: 0.79‐1.55), DFS (HR = 1.66, 95% CI: 0.68‐4.03), or DMFS (HR = 1.18, 95% CI: 0.44‐3.20).ConclusionsThe prognostic role of PD‐L1 in NPC remains unsubstantiated. Future research is needed. Laryngoscope, 130:2598–2606, 2020

Related Organizations

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
United States
Hofstra University
United States

Keywords

Adult, Male, Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms, Middle Aged, Prognosis, Survival Analysis, B7-H1 Antigen, Predictive Value of Tests, Biomarkers, Tumor, Humans, Female, Proportional Hazards Models

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