ABSTRACT Background A sensitive scalp is a particular location of sensitive skin, characterised by the occurrence of unpleasant sensations which cannot be explained by a skin disease. It is a common syndrome that could affect 30%–50% of women. Clinical data are scarce, and the impact on the quality of life poorly described. Objectives The study aimed to assess the characteristics of sensitive scalp, its triggering and alleviating factors and its impact on quality of life (QoL). It also aimed to compare these findings with data from the participants with scalp dermatoses (seborrheic dermatitis or psoriasis). Methods A web questionnaire was sent to adult women via professional mailing lists and social networks. Symptoms and severity were assessed using the Sensitive Scalp Score (3S). The characteristics of sensitive scalp and its impact on QoL were recorded. Participants were also asked about triggering factors and solutions used to reduce the intensity of symptoms, as well as cosmetic consumption data. Results A total of 134 adult women were included in the sensitive scalp group, and 216 in the scalp dermatoses group. In the sensitive scalp group, the 3S score averaged 3.6. Symptoms were present for more than 10 years in 32% of subjects, with itching being the most common symptom. The most frequent triggering factors were tied or braided hair, stress and hair dye. Mechanical factors (scalp massage and hair brushing) were the most frequently cited solutions for reducing sensations. QoL decreased according to the severity of sensitive scalp, with a correlation coefficient equal to 0.579. Conclusions This is the first study to evaluate the characteristics of sensitive scalp and its impact on QoL. Symptoms of sensitive scalp differ from sensory symptoms associated with skin diseases. Consequently, it is important to distinguish between these two conditions.