Chemotherapy against human melanoma in the hamster cheek pouch

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1980 English Publisher:WileyJournal:Journal of Surgical Oncology, volume 15, pages 355-361 (issn: 0022-4790, eissn: 1096-9098,

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Authors: F D, Dufour; G T, Okada; S G, Mah; D L, Morton;

doi: 10.1002/jso.2930150409

pmid: 7453185

Chemotherapy against human melanoma in the hamster cheek pouch

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Abstract

AbstractHuman malignant melanoma was transplanted to the cheek pouch of immuno‐suppressed (corticosteroid‐treated) hamsters. Significant differences were observed in tumor growth constants for animals treated with methotrexate, DTIC, BCNU, and vincristine (P < 0.05) compared to controls. However, no appreciable effect was demonstrated for Adriamycin, 5‐FU, and cytoxan. In addition, single doses as high as 400 mg/kg body weight of methotrexate were no more effective than other agents now used against this neoplasm.

Related Organizations

University of California, Los Angeles
United States
United States Department of Veterans Affairs
United States

Keywords

Male, Brain Neoplasms, Antineoplastic Agents, Neoplasms, Experimental, Middle Aged, Carmustine, Dacarbazine, Cheek, Methotrexate, Doxorubicin, Vincristine, Cricetinae, Animals, Humans, Fluorouracil, Cyclophosphamide, Melanoma, Neoplasm Transplantation

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