AbstractBackgroundPelvic exenteration (PE) is an extensive surgical treatment reserved for advanced or recurrent pelvic neoplasms, with potential impacts on patients' quality of life (QoL) poorly referenced in the literature.ObjectivesThis study aimed to evaluate QoL outcomes among three types of PE.MethodsA cross‐sectional study assessed 106 patients divided into anterior PE (APE), posterior PE (PPE), or total PE (TPE) groups. QoL was measured using e short form 36 version 2 (SF‐36) and the European Organization for Research and Treatment of Cancer QoL Quality of Life Questionnaire Core 30 (QLQ‐C30) QoL questionnaires. Descriptive and inferential analyses compared questionnaire scores.ResultsThe findings unveiled a balance among the three groups concerning demographic variables and comorbidities, with the exception of a male predominance in the APE and TPE cohorts. Notably, the APE group exhibited elevated scores in overall health (assessed via SF‐36) and social functioning and diarrhea domains (assessed via QLQ‐C30). Moreover, in terms of the fatigue and nausea/vomiting domains (assessed via QLQ‐C30), the APE group demonstrated superior QoL compared to the PPE group. Conversely, the PPE group manifested a notably lower QoL in the constipation domain (assessed via QLQ‐C30) compared to the other two groups. Additionally, disease recurrence was significantly associated with diminished QoL across multiple domains.ConclusionAPE patients exhibited better QoL than PPE and TPE groups, with disease recurrence adversely affecting QoL.