Metal Chelates of Alloxan*

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1956 English Publisher:Elsevier BVJournal:Journal of the American Pharmaceutical Association (Scientific ed.), volume 45, pages 699-701 (issn: 0095-9553,

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Authors: W O, FOYE; W E, LANGE;

doi: 10.1002/jps.3030451013

pmid: 13366814

Metal Chelates of Alloxan*

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Abstract

Abstract Alloxan has been found to undergo chelation with Co + + , Ni ++ , and Cu ++ ions in aqueous solution, giving products having a 1:1 ratio of metal to alloxan.The isolated chelates were found to elicit an increase in blood sugar in rabbits comparable to that from alloxan itself, but over a much longer period of time.Metal chelates of two derivatives of alloxan, riboflavin, and its dichloro analog, gave greater increases in blood sugar, which suggests that alloxan may exert its diabetogenic effect as a metal chelate.

Related Organizations

University of Wisconsin–Madison
United States
South Dakota State University
United States

Keywords

Blood Glucose, Metals, Alloxan, Animals, Chelating Agents

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