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Colorimetric assay of digitoxin

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1948Publisher:Elsevier BVJournal:Journal of the American Pharmaceutical Association (Scientific ed.), volume 37, pages 186-188 (issn: 0095-9553,

Authors: Louis W. Green; Frank O. Howland; Alexander T. Warren;

doi: 10.1002/jps.3030370505

pmid: 18865160

Colorimetric assay of digitoxin

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Abstract

A colorimetric method in which sodium beta-naphthoquinone-4-sulfonate (purified) is reacted with digitoxin in alkaline solution to form a purple color is proposed for the determination of digitoxin. The purple color quickly reaches a maximum and fades, but the addition of acetic acid at the time of maximum development changes the color to yellow and stabilizes it. The procedure involves no special equipment and may be adapted to any colorimeter or spectrophotometer by appropriate changes in the digitoxin concentration to suit the particular instrument. Data and tables are given to show results obtained with various samples of digitoxin and with several lots of tablets.

Keywords

Digitalis, Digitoxin, Plant Extracts, Digitalis Glycosides, Biological Assay, Colorimetry

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	18
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average