Pyridazine Derivatives. XI: Antihypertensive Activity of 3-Hydrazinocycloheptyl[1,2-c]pyridazine and Its Hydrazone Derivatives

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1993 Portugal English Publisher:Elsevier BVJournal:Journal of Pharmaceutical Sciences, volume 82, pages 286-290 (issn: 0022-3549,

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Authors: Gil-Longo, José; Laguna, Maria de los Reyes; Verde, Ignacio; Castro, Elena; Fontenla, Jose A.; Terán, Carmen; Orallo, Francisco; +2 Authors

doi: 10.1002/jps.2600820314

pmid: 8450424

handle: 10400.6/558

Pyridazine Derivatives. XI: Antihypertensive Activity of 3-Hydrazinocycloheptyl[1,2-c]pyridazine and Its Hydrazone Derivatives

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Abstract

3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N1-(isopropylidene)]hydrazinocycloheptyl[1,2-c]pyridazine [correction of hydrazinocyclohexyl] (5) and 3-[N1-(isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.

Country

Portugal

Related Organizations

University of Santiago de Compostela
Spain
University of Beira Interior
Portugal

Keywords

Male, Calcium Radioisotopes, Muscle Relaxation, Hydrazones, Aorta, Thoracic, In Vitro Techniques, Hydralazine, Muscle, Smooth, Vascular, Rats, Pyridazines, Rats, Sprague-Dawley, Hydrazines, Rats, Inbred SHR, Animals, Calcium, Female, Isotonic Solutions, Antihypertensive Agents

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